The United States affiliate of the Organization Intersex International (OII)

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5-alpha Reductase

5-ALPHA reductase deficiency, commonly shortened to “5-alpha” by community members and allies, is similar to the androgen resistance syndromes – AIS. Individuals with 5-alpha have XY chromosomes and testes but appear phenotypically female at birth. This variation results from the body’s failure to convert testosterone to dihydrotestosterone, the more powerful form of androgen responsible for the… Continue Reading

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